My 30-something yrs old H150 came with Schaller pup's, "Golden 50s" I think, which I swapped for Seymour Duncan Antiquities, the a SD '59 in the neck, then I put a first production Gibson '57+ (the Tom Holmes ones!) and it always sounded wonderful.
Not for nothing it's called a pick-up, after all the acoustic sound of the guitar is what every pickup has as the basis for the sound it will eventually produce, unless one goes through extreme processing, then the guitar becomes "almost" irrelevant because 99% of what we hear is the effects:
Anyway, few years ago I fitted a set of OX4 "Beano" pups on my H150 (I also have a set of OX4 "Jimmy Page" on my Gibson '58 Reissue) and oh my God, who ever said that perfection is not of this world has never tried this combo! It's just "that" sound and it has everything, sustain, thick while extremely dynamic, sensitive to the touch and changes in Volume or Tone controls on the guitar, a perfect EQ with just the right balance of bass - mids & treble....as I said perfect, and these are the only pups that hit me like that, love at first chord.
I have to say that I tend to go for a very simple set up guitar - 1 or 2 pedals - Marshall on crunch, however I am a professional musicians hance at time I h=found myself playing though elaborate set up, both live and in the studio (I used this guitar straight to the console when laying down parts for a Netflix soundtrack...) nevertheless the results have never been short of impressive!
That's my experience anyway...