Well, to be honest, I use a small hand truck to get my amp from the car to the stage and back - same within my house to the car - so the only lifting I really need to do is to heave it in and out of my car and perhaps occasionally on an amp stand or on to the stage itself. Thankfully, the lifting is so minimal that it doesn't bother me much. If I know that I'll need to haul an amp up and down a full flight of stairs, though, I'll definitely choose a lighter amp. My primary amp is a Two-Rock TS1 combo, and even though it's a 100-watt beast of sorts, between the loop and the master volume control, I can dial it in for the kind of tone I like at any stage volume without having any issues. I'd be the first to say that I'd go for a modeling amp or a much lighter tube amp if I could produce the same kind of vibe that the TS1 puts out, but since I have yet to find anything that'll do that, I just tolerate the weight. Funny, but since the TS1 1x12 combo is still relatively small in size, the other guys in the band think I'm just using a small amp. Little do they know that I could run that same amp at the Madison Square Garden and get away with it.......LOL.